Here are a few suggestions for your next trip from Segrate

In 2 hours, you can reach Milan, Turin, Bologna, Lugano, Verona.

In 3 hours, you can reach Genoa, Florence, Padova.

In 4 hours, you can reach Zürich, Bern, Luzern, Thun.

In 5 hours, you can reach Rome, Genève, Basel, Lausanne, Winterthur, Biel/Bienne, Trieste.

In 6 hours, you can reach Schaan, Monaco, Vaduz, Naples, Lyon, Triesen, Eschen, Nice, Koper, Mauren...